Betadine vs Sterile Water for Periurethral Preparation

Conditions

• Catherization
• Urinary Tract Infection Bacterial

Eligibility Criteria

Sex

FEMALE

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Povidone-Iodine — DRUG
  Providone-Iodine for periurethral preparation
• Sterile water — DRUG
  Sterile water for periurethral preparation

Study Details

The purpose of this study is to determine whether cleaning of the urethra, or external opening to the bladder, with sterile water (water that has been treated to remove bacteria and living organisms) vs Betadine also known as Povidone-Iodine (a medical grade cleaning solution) changes the rates of bacteria in the urine after a temporary catheter, or draining tube, is placed into the bladder. Chemical antiseptics, including Betadine, are the current standard of care. An additional goal of this study is to determine whether cleaning of the urethra, or external opening to the bladder, with sterile water vs betadine changes the amount of discomfort or pain patients experience with placement of a temporary catheter, or draining tube, in the bladder.

Key Dates

Start date

Jun 30, 2025

Status verified

May 2026

Primary completion

May 21, 2028

Completion

May 21, 2028

Study Design

Enrollment

148 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Active Comparator: Betadine
  Betadine periurethral preparation
• Sham Comparator: Sterile Water
  Sterile Water periurethral preparation

Primary Outcome Measure

Bacteruria [ Time Frame: Within 2 weeks of the patients procedure date ]

Central Contacts

• Kathryn C Seymour, MD
  502-588-7660
  [email protected]
• Ankita Gupta, MD, MPH
  502-588-7660

Locations (2)

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