Clinical Alternatives for Reducing Harm Using E-cigarettes

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07039292
Status
Enrolling By Invitation

Conditions

  • E-Cig Use
  • Oncology
  • Smoking

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Harm Reduction (E-cigarette switching) — BEHAVIORAL
    Participants will be assigned to receive an e-cigarette and try to switch completely from smoking to using the e-cigarette
  • Standard of Care — BEHAVIORAL
    Participants will be assigned to receive tobacco treatment referrals and the opportunity to re-enroll in the Tobacco Treatment Program

Study Details

For patients in cancer care, quitting smoking is critical, but a significant portion of patients in cancer care refuse all components of tobacco treatment, even when offered free of charge. The proposed clinical trial will assess one harm reduction intervention, switching completely from cigarettes to e-cigarettes, among oncology outpatients who smoke and refuse traditional tobacco treatment. This study is a type 1 hybrid effectiveness-implementation trial among oncology outpatients at an NCI-designated cancer center who smoke and refuse all components of tobacco treatment (N=208).

Key Dates

Start date
Aug 25, 2025
Status verified
May 2026
Primary completion
May 31, 2029
Completion
Nov 30, 2029

Study Design

Enrollment
208 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Harm Reduction (E-cigarette switching)
    Participants will be assigned to receive an e-cigarette and try to switch completely from smoking to using the e-cigarette
  • Active Comparator: Standard of Care
    Participants will be assigned to receive tobacco treatment referrals and the opportunity to re-enroll in the Tobacco Treatment Program

Primary Outcome Measure

Complete switching [ Time Frame: 6 months ]

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29425-

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By research site
Medical University of South Carolina· Charleston, SC

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