Neuroimaging of Parkinson's

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT07024875
Status
Recruiting
Apply to this trial

Conditions

  • Parkinsons Disease (PD)

Eligibility Criteria

Sex
ALL
Age
40 Years - N/A
Healthy Volunteers
Accepted

Study Details

Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.

Key Dates

Start date
Aug 1, 2025
Status verified
Apr 2026
Primary completion
Jan 31, 2031
Completion
Jan 31, 2031

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Parkinson's Participants
    * 70 non-demented individuals with clinically definite PD * Must be 40 years of age or older * Both male \& female
  • Arm: Healthy Control
    * 50 individuals with normal neurological exams and cognition * No first-degree relatives with PD * Also, must be 40 years of age or older

Primary Outcome Measure

Cortico-subcortical connectivity to SCAN vs effectors [ Time Frame: 6 months per participant; 3-4 sessions for controls, 6-8 sessions for PD patients ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
East Imaging BuildingSt LouisMissouri63110-

Find similar trials in St Louis, MO

By research site
East Imaging Building· St Louis, MO

Related Studies