Laser Ablation a Salvage Treatment for Obstructive Benign Prostatic Hyperplasia

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT07016620
Status
Recruiting
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Conditions

  • Benign Prostatic Hyperplasia (BPH)

Eligibility Criteria

Sex
MALE
Age
40 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Transperineal Laser Ablation (TPLA) — PROCEDURE
    Outpatient treatment with Transperineal Laser Ablation (TPLA) as a salvage therapy after previous Minimally Invasive Surgical Therapies (MIST)

Study Details

Benign prostatic hyperplasia (BPH) is a common condition affecting aging men, often leading to lower urinary tract symptoms (LUTS). While Minimally Invasive Surgical Therapies (MIST) procedures offer less invasive alternatives to traditional surgery, some patients experience symptom recurrence or require further intervention due to lack of adequate relief of obstruction. Treatment of persistent obstruction after MIST therapy (BPH salvage therapy) typically requires surgical intervention like transurethral resection of prostate (TURP). This study proposes to evaluate the effectiveness of in-office transperineal laser ablation (TPLA) using the Echolaser system as a minimally invasive treatment option for these patients, potentially avoiding more invasive surgical procedures. The Cleveland Clinic sees a high volume of BPH salvage patients, making this an ideal setting for this research.

Key Dates

Start date
Jan 12, 2026
Status verified
Feb 2026
Primary completion
Sep 1, 2026
Completion
Sep 1, 2027

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: Transperineal Laser Ablation (TPLA)
    Patients with recurrent Benign Prostatic Hyperplasia (BPH) after Minimally Invasive Surgical Therapies previous (MIST)

Primary Outcome Measure

Evaluate the impact of in-office TPLA on voiding function in patients with recurrent BPH after prior MIST procedures [ Time Frame: baseline, and then 1-, 3-, 6- and 12-months post-treatment with laser ablation ]

Locations (1)

FacilityCityStateZIPSite coordinators
Cleveland ClinicClevelandOhio44195
Petar Bajic, MD
[email protected]
216-444-1231
Raevti Bole, MD
[email protected]
216 445-8640
Petar Bajic, MD (PRINCIPAL_INVESTIGATOR)
Raevti Bole, MD (SUB_INVESTIGATOR)

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