Effect of Valaciclovir on Inter-Appointment Pain in Endodontic Treatment of Necrotic Teeth

Conditions

• Symptomatic Apical Periodontitis

Eligibility Criteria

Sex

ALL

Age

18 Years - 60 Years

Healthy Volunteers

Not accepted

Interventions

• Valacyclovir — DRUG
  valacyclovir group received 2 g (two 1 g tablets) one hour prior to treatment, followed by 2 g 12 hours later, and 1 g at both 24 and 36 hours post-treatment
• Placebo — DRUG
  The control group received a placebo identical in appearance and administration schedule

Study Details

Aim: To investigate the effect of oral valacyclovir on inter-appointment endodontic pain in single-rooted necrotic teeth diagnosed with symptomatic apical periodontitis (SAP). Materials and Methods: This study was a randomized, triple-blind, placebo-controlled clinical trial conducted on 38 teeth. Participants were assigned to intervention or control groups using stratified randomization based on gender and baseline pain severity. Both groups received similar root canal treatment; the only difference was the administration of valacyclovir in the intervention group and placebo in the control group. Patients' pain levels were monitored and recorded at 6, 24, and 48 hours post-treatment using a Visual Analog Scale (VAS), along with their consumption of analgesic (ibuprofen).

Key Dates

Start date

Nov 1, 2024

Status verified

Jun 2024

Primary completion

Mar 22, 2025

Completion

Mar 26, 2025

Study Design

Enrollment

38 participants (actual)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Placebo Comparator: placebo group
• Experimental: valacyclovir group

Primary Outcome Measure

Pain intensity measured by Visual Analog Scale (VAS) [ Time Frame: 6, 24, and 48 hours post-treatment ]