A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07006506
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Belumosudil — DRUG
    Belumosudil is an oral selective inhibitor of Rho-GTPase-associated coiled-coil kinase 2 (ROCK2)

Study Details

The purpose of this study is to find out whether adding belumosudil to a usual approach for reducing the risk of graft-versus-host disease (GVHD) may be an effective GVHD prevention approach for people with blood cancer who have a stem cell transplant. The investigators will also look at the safety of the study approach.

Key Dates

Start date
May 21, 2025
Status verified
Apr 2026
Primary completion
May 21, 2029
Completion
May 21, 2029

Study Design

Enrollment
46 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with hematologic malignancy in morphologic remission
    Participants will be diagnosed with a hematologic malignancy in morphologic remission

Primary Outcome Measure

Change in GVHD/relapse-free survival (GRFS) at 1-year post-Hematopoietic Cell Transplantation (HCT) [ Time Frame: 1 year ]

Central Contacts

Locations (8)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Doris Ponce, MD
646-608-3739
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Doris Ponce, MD
646-608-3739
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Doris Ponce, MD
646-608-3739
Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity)CommackNew York11725
Doris Ponce, MD
646-608-3739
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Doris Ponce, MD
646-608-3739
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Doris M Ponce, MD
646-608-3739
New York University (Data Collection Only)New YorkNew York10010
Jingmei Hsi, MD
646-501-4848
Memorial Sloan Kettering Nassau (Limited Protocol Activites)Rockville CentreNew York11553
Doris Ponce, MD
646-608-3739

Find similar trials in Basking Ridge, NJ

By research site
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk-Commack (Limited protocol activity)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

Related Studies