Effects of Cannabidiol on Stress and Nicotine Withdrawal

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT07001930
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • CBD
  • Nicotine Dependence
  • Stress
  • Tobacco Smoking

Eligibility Criteria

Sex
ALL
Age
21 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Epidiolex — DRUG
    Oral cannabidiol

Study Details

The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between these types of stress. Participants will be administered CBD and exposed to stress. Biological and subjective measures will be collected. Participants may be asked to stop use for 24 hours. Researchers will also investigate withdrawal effects between participants who have not smoked nicotine in 24 hours and those who have continued to smoke before each session.

Key Dates

Start date
Aug 25, 2025
Status verified
Aug 2025
Primary completion
Sep 1, 2029
Completion
Sep 1, 2029

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Ad Lib (first)
    Participants who use tobacco cigarettes and will be randomly assigned to smoking ab lib. Each participant will receive 0, 200, 400 mg of CBD in this arm.
  • Experimental: Abstinence (first)
    Participants who use tobacco cigarettes and will be randomly assigned to smoking abstinence for 24 hours before each session. Each participant will receive 0, 200, 400 mg of CBD in this arm.

Primary Outcome Measure

Negative Affect as assessed by the Subjective State Scale [ Time Frame: 20 minutes, 70 minutes, 120 minutes, 170 minutes, 190 minutes, 200 minutes, 220 minutes timepoints ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Behavioral Pharmacology Research UnitBaltimoreMaryland21224-

Find similar trials in Baltimore, MD

By research site
Behavioral Pharmacology Research Unit· Baltimore, MD

Related Studies