Substrates for Post-Stroke Arm Rehabilitation

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT06998485
Status
Recruiting
Apply to this trial

Conditions

  • Neurorecovery
  • Stroke
  • Stroke Rehabilitation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Arm Basis Training — BEHAVIORAL
    This program is a systematic training regimen specifically designed to improve proximal motor control for patients with severe upper extremity hemiparesis. The core principles of the Arm Basis Training Program focus on rebuilding the fundamental capacity for specific and selective motor control before progressing to more complex motor patterns.

Study Details

Difficulty moving the arm is very common and a major cause of disability after stroke. Although rehabilitation therapies (i.e., occupational and physical therapy) are the most common treatments used to improve arm motor function, it remains unknown how therapy actually changes brain pathways after stroke. This project seeks to generate fundamental knowledge about brain pathways that allow people to move their arm after stroke and how these pathways change with rehabilitation; we expect this knowledge to translate to new therapies to reduce stroke-related disability. We plan to enroll N = 50 patients with moderate to severe difficulty moving their arm after ischemic or hemorrhage stroke during the subacute period (3 to 6 months post stroke) into either 30 hours over 6 weeks of Arm Basis Training (a protocolized form of occupational therapy targeting motor control) or usual care. We will perform kinematic motor assessments, neuroimaging, and neurophysiology before and after therapy in order to test the hypothesis that intensive, target training improves arm motor control and induces corresponding anatomical and physiological changes of associated brain pathways.

Key Dates

Start date
Oct 7, 2025
Status verified
Mar 2026
Primary completion
Apr 30, 2030
Completion
Apr 30, 2030

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Arm Basis Training
    This program is a systematic training regimen specifically designed to improve proximal motor control for patients with severe upper extremity hemiparesis. The core principles of the Arm Basis Training Program focus on rebuilding the fundamental capacity for specific and selective motor control before progressing to more complex motor patterns.
  • No Intervention: Usual Care Occupational Therapy
    Usual care occupational therapy. Participants will be asked to keep logs of the therapy they receive.

Primary Outcome Measure

Change in Kinematic Measure of Upper Extremity Motor Control [ Time Frame: Pre- and post- 6 weeks of therapy ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Laboratory for Translational Neurorecovery, Center for Neurotechnology and Neurorecovery, Massachusetts General HospitalBostonMassachusetts02114
Caroline Lambert
[email protected]
617-726-1311
Julie DiCarlo
[email protected]
617-726-1311

Find similar trials in Boston, MA

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Laboratory for Translational Neurorecovery, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital· Boston, MA

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