A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Part of paid clinical trials in Beverly Hills, California.

Sponsor
Pfizer
Study ID
NCT06991257
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 79 Years
Healthy Volunteers
Not accepted

Interventions

  • Placebo — DRUG
    ARM 1
  • Low Dose PF-07328948 — DRUG
    ARM 2
  • Medium Dose PF-07328948 — DRUG
    ARM 3
  • High Dose PF-07328948 — DRUG
    ARM 4

Study Details

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

Key Dates

Start date
Jun 19, 2025
Status verified
May 2026
Primary completion
Nov 16, 2027
Completion
Dec 14, 2027

Study Design

Enrollment
620 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: ARM 1
    Placebo Participants will receive Placebo for up to 36 weeks
  • Experimental: ARM 2
    Low dose PF-07328948 Participants will receive PF-07328948 for up to 36 weeks
  • Experimental: ARM 3
    Medium dose PF-07328948 Participants will receive PF-07328948 for up to 36 weeks
  • Experimental: ARM 4
    High dose PF-07328948 Participants will receive PF-07328948 for up to 36 weeks

Primary Outcome Measure

Number of Participants with Clinical Events [ Time Frame: over 36 weeks ]

Central Contacts

Locations (28)

FacilityCityStateZIPSite coordinators
National Heart InstituteBeverly HillsCalifornia90211-
Orange County Research CenterLake ForestCalifornia92630-
Comprehensive Cardiovascular CareSanta MariaCalifornia93454-
FOMAT Medical ResearchSanta MariaCalifornia93454-
FWD Clinical ResearchBoca RatonFlorida33486-
Jacksonville Center for Clinical ResearchJacksonvilleFlorida32216-
Flourish Research Acquisition, LLC dba Flourish Research - North MiamiMiamiFlorida33138-
Infinite Clinical ResearchMiamiFlorida33133-
Amavita Research ServicesNorth Miami BeachFlorida33169-
Clinical Site Partners, LLC dba Flourish ResearchWinter ParkFlorida32789-
NMH Clinical Research UnitChicagoIllinois60611-
Northwestern Memorial HealthCare - Arkes PavilionChicagoIllinois60611-
Northwestern Memorial HealthCare - Feinberg PavilionChicagoIllinois60611-
Northwestern Memorial HealthCare - Galter PavilionChicagoIllinois60611-
Northwestern Memorial Hospital Investigational Drug Service (IDS)ChicagoIllinois60611-
Northwestern UniversityEvanstonIllinois60208-
Chicago Medical ResearchHazel CrestIllinois60429-
NexGen ResearchFort WayneIndiana46804-
Reid Physician AssociatesRichmondIndiana47374-
Ascension Saint Agnes Heart CareBaltimoreMaryland21229-
Chesapeake Cardiac CareBowieMaryland20715-
Flourish Research - BowieBowieMaryland20715-
Velocity Clinical Research, Lincoln, Pioneer Heart InstituteLincolnNebraska68510-
NexGen ResearchLimaOhio45801-
Headlands Horizons, LLC dba Headlands Research-BrownsvilleBrownsvilleTexas78526-
Valley Regional Medical CenterBrownsvilleTexas78526-
North Dallas Research AssociatesMcKinneyTexas75069-
Northwest Houston Heart CenterTomballTexas77375-

Find similar trials in Beverly Hills, CA

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
National Heart Institute· Beverly Hills, CAOrange County Research Center· Lake Forest, CAComprehensive Cardiovascular Care· Santa Maria, CAFOMAT Medical Research· Santa Maria, CAFWD Clinical Research· Boca Raton, FLJacksonville Center for Clinical Research· Jacksonville, FL

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