Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery

Conditions

• Brain Function
• Hemiarch Cardiac Procedure

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Antegrade Perfusion — PROCEDURE
  Procedure in which the surgeon accesses one of two arteries that branch off from the aorta to provide blood to the brain.
• Retrograde Perfusion — PROCEDURE
  Procedure in which the surgeon accesses the superior vena cava to supply blood to the brain.

Study Details

The purpose of this study is to compare brain function after surgical circulatory arrest using either antegrade perfusion or retrograde perfusion.

Key Dates

Start date

Apr 18, 2025

Status verified

Aug 2025

Primary completion

Dec 31, 2026

Completion

Mar 31, 2027

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Active Comparator: Arm 1: Antegrade Perfusion
  In antegrade perfusion, the surgeon accesses one of two arteries that branch off from the aorta (the artery that delivers blood to the rest of the body) to provide blood to the brain.
• Active Comparator: Arm 2: Retrograde Perfusion
  In retrograde perfusion, the surgeon accesses the superior vena cava (large vein bringing blood back to the heart) to supply blood to the brain.

Primary Outcome Measure

Change in neurocognitive function as measured by the Montreal Cognitive Assessment (MoCA) [ Time Frame: Baseline to 4 weeks ]

Central Contacts

• Kelly Rodden, BSN
  9196811804
  [email protected]
• Bonita Hilliard, RPM
  [email protected]

Locations (2)

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