The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Beth Israel Deaconess Medical Center
Study ID
NCT06983730
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Healthy Volunteer Study
  • Heat Strain
  • Kidney Dysfunction

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Vitamin B3 — DIETARY_SUPPLEMENT
    1000mg once a day orally for two days, once the day before the exercise session, and once the day of the exercise session.

Study Details

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?

Key Dates

Start date
Jan 26, 2026
Status verified
Feb 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
28 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Vitamin B3, then placebo
    Individuals will receive 1000mg oral Vitamin B3 daily for two days leading up to their first exercise session, and oral placebo daily for two days leading up to their second exercise session.
  • Experimental: Placebo, then vitamin B3
    Individuals will receive 1000mg oral placebo daily for two days leading up to their first exercise session, and oral vitamin B3 daily for two days leading up to their second exercise session.

Primary Outcome Measure

Urinary neutrophil gelatinase-associated lipocalin [ Time Frame: Pre- and immediately post- heat stress exposure ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Beth Israel Deaconess Medical CenterBostonMassachusetts02215
Nathan H Raines, MD MPH
[email protected]
703-927-0992
Nathan H Raines, MD MPH (PRINCIPAL_INVESTIGATOR)
Boston UniversityBostonMassachusetts02215
Dustin Allen, PhD
[email protected]
417-693-2182
Dustin Allen, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Boston, MA

By research site
Beth Israel Deaconess Medical Center· Boston, MABoston University· Boston, MA

Related Studies