Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.

Part of paid clinical trials in Houston, Texas.

Sponsor
Colgate Palmolive
Study ID
NCT06966492
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Gingival Inflammation

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Stannous Fluoride Toothpaste (SnF) — DRUG
    stannous fluoride toothpaste

Study Details

This is a clinical research study designed to measure changes in inflammation and the oral microbiome during a phase of good oral hygiene and the absence of oral hygiene. The goal of the study is to investigate the interplay between local oral inflammation, microbiota and systemic immune responses.

Key Dates

Start date
Jun 30, 2026
Status verified
May 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Control
    Regular fluoride toothpaste
  • No Intervention: Test
    Stannous fluoride containing toothpaste

Primary Outcome Measure

Gingival Bleeding Index described by Ainamo & Bay, 1976 [ Time Frame: From enrollment and at each successive visit until to the end of the study ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UT Health School of DentistryHoustonTexas77054
Roger Arce, Assoc Prof, Dept. of Periodontics & Oral Hygiene, DDS, MS, PhD
[email protected]
713-486-4382

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By research site
UT Health School of Dentistry· Houston, TX

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