Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 2)

Part of paid clinical trials in Houston, Texas.

Sponsor
The University of Texas Health Science Center, Houston
Study ID
NCT06961916
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Interventions

  • Active rTMS — DEVICE
    Active H-coil delivered rTMS sessions will be given three times per treatment visit for up to 10 visits within about 2 weeks. There are about 30 minutes breaks between adjacent TMS sessions. Each TMS session takes about 3 to 4 minutes to complete.
  • Cognitive Training — BEHAVIORAL
    For the cognitive training sessions, patients will be asked to play cognitive computer games involving processing speed tasks for about 15 to 30 minutes.

Study Details

Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from H coil combined with cognitive training for improving white matter integrity.

Key Dates

Start date
Jun 3, 2025
Status verified
Jun 2025
Primary completion
May 1, 2029
Completion
May 1, 2029

Study Design

Enrollment
120 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Active rTMS combined with Cognitive Training
    Participants will receive active H-coil delivered rTMS, as well as cognitive training in each treatment visit for up to 10 treatment visits within about 2 weeks. In each visit, there are three rTMS sessions and each of them is followed by a cognitive training session and a rest period, which allows the inter-rTMS-session interval to be about 30 minutes.

Primary Outcome Measure

Brain microstructural integrity as indicated by white matter fractional anisotropy (FA) values as assessed by magnetic resonance imaging (MRI) [ Time Frame: baseline, visit 6 (about 1 week after baseline), visit 10 (about 2 weeks after baseline) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas Health Science Center, HoustonHoustonTexas77054
Xiaoming Du, PhD
[email protected]
410-402-6036
Bhim Adhikari
[email protected]
713-486-2740

Find similar trials in Houston, TX

By condition
Schizophrenia
By specialty
PsychiatryMental healthBehavioral health
By research site
The University of Texas Health Science Center, Houston· Houston, TX

Related Studies