Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT06954675
Status
Recruiting
Apply to this trial

Conditions

  • Microbiome Analysis

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Exogenous ketone ester — DIETARY_SUPPLEMENT
    25g Bis-octanoyl-(R)-1,3-butanediol (C8)

Study Details

The goal of this observational study is to learn if a ketone ester can improve the content of the gut microbiome. The main questions it aims to answer are: * Does a ketone ester reduce age-related signatures in the gut microbiome? * What changes occur in the gut microbiome after consuming a ketone ester? Participants will: * Take a ketone ester every day for seven (7) days * Collect and ship stool samples within seven (7) days before, during, and within seven (7) days after the study period * Measure their ketone levels with a urine strip every day after having the drink * Answer questions about their typical diet on a normal day * Record their symptoms, if any arise

Key Dates

Start date
Nov 21, 2025
Status verified
Jan 2026
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: 25g Bis-octanoyl-(R)-1,3-butanediol (C8)
    Participants will receive 25g of the ketone ester bis-octanoyl-(R)-1,3-butanediol (C8) daily.

Primary Outcome Measure

Longitudinal Change in Microbiome Composition [ Time Frame: From baseline sampling to final sampling, including intervention period, at 21 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCSF Wayne and Gladys Valley Center for VisionSan FranciscoCalifornia94158
Sidharth S Madhavan, PhD
[email protected]
248-797-1025
John C Newman, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in San Francisco, CA

By research site
UCSF Wayne and Gladys Valley Center for Vision· San Francisco, CA

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