Influence of the Gut Microbiome on Blueberry Polyphenol Metabolites

Part of paid clinical trials in Fort Collins, Colorado.

Sponsor
Colorado State University
Study ID
NCT07607158
Status
Recruiting
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Conditions

  • Metabolomics
  • Microbiome Analysis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Freeze-dried blueberry powder beverage — OTHER
    Participants will consume a single oral dose of a standardized blueberry beverage prepared with 22 g of freeze-dried blueberry powder reconstituted in approximately 480 mL of distilled water. The beverage will be consumed in its entirety at the start of the test visit following an overnight fast. This dose is selected to provide a defined quantity of blueberry-derived polyphenols for pharmacokinetic assessment. No additional interventions or comparator treatments will be administered.

Study Details

The objective of this study is to determine whether inter-individual differences in the gut microbiome influence exposure to blueberry polyphenol metabolites. We will use pharmacokinetics of blueberry polyphenols after an acute blueberry exposure to group individuals into "metabotypes", groups of individuals based on similarity in their metabolite profiles. We will then use multi-omic approaches to determine whether the gut microbiome predicts an individual's metabotype.

Key Dates

Start date
Jan 27, 2026
Status verified
May 2026
Primary completion
Mar 1, 2027
Completion
Jan 1, 2028

Study Design

Enrollment
125 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Single-arm
    All participants will receive a single dose of the blueberry intervention to characterize pharmacokinetic profiles of polyphenol metabolites.

Primary Outcome Measure

Pharmacokinetics - Area under the curve (AUC) of circulating blueberry polyphenol metabolites [ Time Frame: Baseline and 1, 2, 4, 6, 8 and 24 hours post-consumption ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Colorado State University; Food and Nutrition Clinical Research Laboratory; Gifford Building Room 216; 502 West Lake Street, Fort Collins, CO 80523Fort CollinsColorado80523
Jenny Whittington, MS
[email protected]
970-310-6843
Tiffany Weir, PhD
[email protected]
Tiffany Weir, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Fort Collins, CO

By research site
Colorado State University; Food and Nutrition Clinical Research Laboratory; Gifford Building Room 216; 502 West Lake Street, Fort Collins, CO 80523· Fort Collins, CO

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