Resilience Among Individuals With Opioid Use Disorder

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT06954402
Status
Recruiting
Apply to this trial

Conditions

  • Opioid Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Acute Stress Intervention (MAST-based) — BEHAVIORAL
    This intervention uses the Maastricht Acute Stress Test (MAST) to induce an acute stress response. Participants are exposed to standardized stress tasks while performing laboratory-based assessments of cognitive, emotional, and control aspects of resilience.
  • Non-Stress Intervention (NST-based) — BEHAVIORAL
    In this control intervention, participants complete the same battery of laboratory tasks without exposure to the acute stressor.

Study Details

The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress and non-stress situations.

Key Dates

Start date
May 29, 2026
Status verified
May 2026
Primary completion
Apr 30, 2029
Completion
Apr 30, 2029

Study Design

Enrollment
125 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Stress-First Sequence
    Participants in this arm will first undergo the stress condition using the Maastricht Acute Stress Test (MAST) and then complete the non-stress condition (NST) in a subsequent session.
  • Experimental: Non-Stress-First Sequence
    Participants in this arm will first complete the non-stress condition (NST) and then undergo the stress condition using the Maastricht Acute Stress Test (MAST) in a subsequent session.

Primary Outcome Measure

Self-Reported Trait Resilience as assessed by Connor-Davidson Resilience Scale 25 (CD-RISC-25) [ Time Frame: Immediately after completing the task ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Johns Hopkins University Bayview Medical CampusBaltimoreMaryland21224-
Johns Hopkins University Bayview Medical CampusBaltimoreMaryland21224
Alec Zhang, BS
[email protected]
410-550-4121

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By research site
Johns Hopkins University Bayview Medical Campus· Baltimore, MD

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