Optimal Measurement of Spleen Stiffness Among Veterans With Metabolic Dysfunction-Associated Steatotic Liver Disease

Conditions

• Metabolic-dysfunction-associated Fatty Liver Disease (MAFLD)

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Vibration-controlled transient elastography — DEVICE
  Liver and spleen stiffness measurements using vibration-controlled transient elastography

Study Details

A growing number of people are being diagnosed with fatty liver disease, also known as metabolic-dysfunction associated liver disease (MASLD). Fatty liver disease can unknowingly progress to serious liver disease and even permanent scarring (cirrhosis).The purpose of this research is to learn the best way to detect serious liver disease as early as possible in patients with fatty liver disease by measuring the stiffness of the spleen. Secondarily, the study hopes to understand how the stiffness of the spleen relates to the severity of liver disease.

Key Dates

Start date

Apr 8, 2025

Status verified

Apr 2025

Primary completion

Jun 30, 2026

Completion

Jul 31, 2026

Study Design

Enrollment

100 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Arms

• Experimental: Spleen Stiffness Measurements
  Participants with metabolic-dysfunction associated steatotic liver disease will undergo liver and spleen stiffness measurements using vibration-controlled transient elastography

Primary Outcome Measure

Spleen Stiffness measurement [ Time Frame: 1 year ]

Locations (1)

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