Vaping and Smoking Project in People With Schizophrenia

Conditions

• Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

Eligibility Criteria

Sex

ALL

Age

21 Years - 50 Years

Healthy Volunteers

Not accepted

Interventions

• Acute (24-hour) abstinence — BEHAVIORAL
  Participants will be asked to abstain from all tobacco/nicotine for 24 hours prior to the visit
• Ad libitum smoking/vaping — BEHAVIORAL
  Participants will be asked to smoke/vape as usual during the 24 hours prior to the visit

Study Details

The proposed research will characterize withdrawal among people with schizophrenia who vape daily compared to people with schizophrenia who smoke combustible cigarettes daily, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence and contributing to the development of vaping cessation interventions amongst people with schizophrenia, the leading preventable cause of death in the US.

Key Dates

Start date

Feb 15, 2025

Status verified

Mar 2026

Primary completion

Apr 1, 2027

Completion

Apr 1, 2027

Study Design

Enrollment

64 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Other: Daily use of ENDS
  Participants who use nicotine-containing ENDS daily or near-daily but who do NOT smoke combustible cigarettes daily or near-daily.
• Other: Daily use of combustible cigarettes
  Participants who smoke combustible cigarettes daily or near-daily but do NOT use nicotine-containing ENDS daily or near-daily.

Primary Outcome Measure

Wisconsin Smoking Withdrawal Scale - anger 0.5 [ Time Frame: 0.5 hours ]

Central Contacts

• Larry Hawk, PhD
  716-645-0192
  [email protected]

Locations (1)

Find similar trials in Buffalo, NY

Related Studies

• Vaping and Smoking Withdrawal Project
  Recruiting · State University of New York at Buffalo · Buffalo, New York