Vaping and Smoking Withdrawal Project

Part of paid clinical trials in Buffalo, New York.

Sponsor
State University of New York at Buffalo
Study ID
NCT05772845
Status
Recruiting
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Conditions

  • Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

Eligibility Criteria

Sex
ALL
Age
21 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Acute (24-hour) abstinence — BEHAVIORAL
    Participants will be asked to abstain from all tobacco/nicotine for 24 hours prior to the visit
  • Ad libitum smoking/vaping — BEHAVIORAL
    Participants will be asked to smoke/vape as usual during the 24 hours prior to the visit

Study Details

The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence/abuse liability and contributing to the development of therapies for tobacco/nicotine use, the leading preventable cause of death in the US.

Key Dates

Start date
Feb 14, 2023
Status verified
Mar 2026
Primary completion
Nov 30, 2026
Completion
Nov 30, 2026

Study Design

Enrollment
370 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Daily Users of ENDS
    Participants who use nicotine-containing ENDS daily or near-daily but who do NOT smoke combustible cigarettes daily or near-daily.
  • Other: Daily Users of Combustible Cigarettes
    Participants who smoke combustible cigarettes daily or near-daily but do NOT use nicotine-containing ENDS daily or near-daily.
  • Other: Daily Dual Users of ENDS and Combustible Cigarettes
    Participants who both use nicotine-containing ENDS and combustible cigarettes daily or near-daily

Primary Outcome Measure

Wisconsin Smoking Withdrawal Scale - anger 0.5 [ Time Frame: 0.5 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University at BuffaloBuffaloNew York14260
Larry Hawk, PhD
[email protected]
7166450192

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By research site
University at Buffalo· Buffalo, NY

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