Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Human Genome Research Institute (NHGRI)
Study ID
NCT06944067
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
2 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

The purpose of this research study is to look at genes and determine how they interact with each other to find changes that could explain why some people's immune systems may respond to blood transfusions. This response is called an alloimmune response. We strongly believe that when someone has an alloimmune response, it is caused by changes in their genes. We plan to compare changes in the genes of individuals that develop red blood cell alloimmunization after blood transfusions with those that do not develop alloimmunization. This may help us to create more targeted therapeutic interventions, which may improve the health of alloimmune responders.

Key Dates

Start date
Jun 24, 2025
Status verified
May 2026
Primary completion
Apr 10, 2030
Completion
Apr 10, 2030

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Alloimmune non-responders
    Individuals with sickle cell disease who have received blood transfusions but never had an alloimmune response to transfusion.
  • Arm: Alloimmune responders
    Individuals with sickle cell disease who have a history of an alloimmune response when receiving blood transfusions.

Primary Outcome Measure

Completion of analysis of previously identified risk loci to determine the relationship between genome structure and expression. [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
NIH Clinical Center Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

Find similar trials in Bethesda, MD

By condition
Sickle cell disease
By research site
National Institutes of Health Clinical Center· Bethesda, MD

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