Huntington's Disease Biobank: Advancing Remote Monitoring and Deep Phenotyping

Part of paid clinical trials in Palo Alto, California.

Sponsor
Stanford University
Study ID
NCT06941662
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Interventions

  • computer vision, remote monitoring, blood, urine, wrist bands, mobile-app — DIAGNOSTIC_TEST
    This is a low burden study that relies on a combination of cutting edge remote monitoring methods to deliver individualized evaluations to participants in their homes.

Study Details

This observational study aims to identify novel biomarkers of disease onset and progression in Huntington's disease by integrating remote monitoring with fluid biomarkers. Using video-based computer vision and mobile app-based cognitive assessments combined with machine learning algorithms, we aim to develop markers that can be used by Huntington's disease patients at home. Using machine learning to analyze videos of movement will capture the movements with an accuracy that will be as good as seeing an expert neurologist. These individualized markers can be followed over time to evaluate symptoms onset and change. The study will track disease progression and correlate these digital markers with changes in plasma and cerebrospinal fluid. The ultimate goal is to advance biomarker discovery and therapeutic development for Huntington's disease. The study includes one in-person visit per year. A remote visit via Zoom or Facetime (15 min) every three months to record videos of movement. We can also share cutting-edge wristbands and a mobile phone app.

Key Dates

Start date
Jun 1, 2024
Status verified
Apr 2025
Primary completion
Dec 31, 2035
Completion
Dec 31, 2035

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Huntington's disease
    Individuals who carry the Huntington's disease mutation. Individuals with pre-manifest or manifest disease at all disease stages are welcome

Primary Outcome Measure

Unified Huntington's Disease Rating Scale (UHDRS) [ Time Frame: Once a year in-person and 3 times a year remotely, until death or dropout of the study (average approximately 1 year) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford UniversityPalo AltoCalifornia94304
Minhtrang Chu, Study Coordinator
[email protected]
650-250-3160
Olivia Lu, Study Coordinator
[email protected]
650-374-9286
Kyan Younes, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Palo Alto, CA

By condition
Huntington disease
By specialty
NeurologyBrain disorders
By research site
Stanford University· Palo Alto, CA

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