A Trial of D-mannose for the Prophylaxis of Recurrent Urinary Tract Infections

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT06940622
Status
Recruiting
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Conditions

  • Cystitis Chronic
  • Cystitis Recurrent
  • Recurrent UTIs
  • Recurrent Urinary Tract Infection
  • Recurrent Urinary Tract Infections
  • Recurrent Urinary Tract Infections in Women
  • UTI
  • UTI - Lower Urinary Tract Infection
  • UTI - Urinary Tract Infection

Eligibility Criteria

Sex
FEMALE
Age
55 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • D-Mannose — DIETARY_SUPPLEMENT
    D-mannose (2g, i.e., 4 x 500mg capsules) daily for 12 months.
  • Placebo — DIETARY_SUPPLEMENT
    Placebo daily for 12 months.

Study Details

A randomized, double-blind, placebo-controlled, 12-month study to determine the effectiveness of D-mannose (2g daily) supplementation in rUTI (recurrent urinary tract infection) prevention in post-menopausal women.

Key Dates

Start date
Aug 1, 2025
Status verified
Sep 2025
Primary completion
Sep 30, 2029
Completion
Sep 30, 2030

Study Design

Enrollment
90 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: D-mannose
    Dietary Supplement: D-Mannose
  • Placebo Comparator: Placebo
    Dietary Supplement: Placebo

Primary Outcome Measure

Failure rate [ Time Frame: Through study completion, an average of 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Texas Southwestern Medical CenterDallasTexas75390
Sonobia Garrett, BSHS
[email protected]
214-645-8787
[email protected]
Philippe E Zimmern, MD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Texas Southwestern Medical Center· Dallas, TX

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