Daily Nitrofurantoin Versus Bladder Fulguration Plus Daily Nitrofurantoin for Women With Recurrent Urinary Tract Infections

Part of paid clinical trials in Kansas City, Kansas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT06907199
Phase
PHASE1
Status
Recruiting
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Conditions

  • Cystitis Recurrent
  • Recurrent UTIs

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Electrofulguration (EF) — PROCEDURE
    Nitrofurantoin (NF) daily antibiotic prophylaxis for 6 months plus Electrofulguration.
  • Nitrofurantoin (NF) — DRUG
    Nitrofurantoin (NF) daily antibiotic prophylaxis given daily for 6 months.

Study Details

The goal of this clinical trial is to learn if the drug Nitrofurantoin (NF) taken as a daily antibiotic, works to treat cystitis compared to electrofulguration (EF) and Nitrofurantoin (NF) daily antibiotic.

Key Dates

Start date
Apr 6, 2026
Status verified
Apr 2026
Primary completion
Jul 1, 2028
Completion
Jan 30, 2029

Study Design

Enrollment
104 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Nitrofurantoin (NF) daily antibiotic prophylaxis
    Nitrofurantoin (NF) daily antibiotic prophylaxis given daily for 6 months.
  • Experimental: Nitrofurantoin (NF) daily antibiotic prophylaxis plus electrofulguration (EF)

Primary Outcome Measure

Treatment of cystitis with NF vs EF+NF [ Time Frame: Baseline to 30 months after enrollment to completion of study ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
The University of KansasKansas CityKansas66160
Colby Souders, MD
[email protected]
913-588-6146
Colby Souders, MD (PRINCIPAL_INVESTIGATOR)
UT Southwestern Medical CenterDallasTexas75390
Meghan B Leak
[email protected]
214-645-8787
Jessica de Araujo Paula
[email protected]
214-645-8787
Philippe Zimmern, MS (PRINCIPAL_INVESTIGATOR)
Colby Souders, MD (SUB_INVESTIGATOR)

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By research site
The University of Kansas· Kansas City, KSUT Southwestern Medical Center· Dallas, TX

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