Pediatric Neuroimaging

Conditions

• Neurogimaging

Eligibility Criteria

Sex

ALL

Age

9 Years - 14 Years

Healthy Volunteers

Accepted

Study Details

Background: Puberty is a normal part of life. Many big changes occur in all parts of the body as a child matures into an adult. Researchers in this study want to find out more about how the brain changes during puberty. Objective: To study changes that occur in the brain before, during, and after puberty. Eligibility: Healthy children aged 9 to 14 years. Design: Participants will have 2 clinic visits. Each visit will last up to 4 hours. In the first visit, participants will be screened: They will have a physical exam with blood tests. They will complete a mental health questionnaire on a computer. They will undergo a mock magnetic resonance imaging (MRI) scan. Participants will be made comfortable as they lie on the table and slide into the big tube. They will learn what it feels and sounds like to lie still inside a real MRI. At the second visit, participants will have more tests: They will have a physical exam with blood tests. This time the doctor will check for their stage of puberty. The doctor will look at and touch their genitals and breasts. They will have a real MRI exam. An x-ray will be taken of their hand and wrist. This will show how their bones are maturing. They will have a DEXA scan. They will lie on a table while a machine uses x-rays to measure the makeup of their bodies, including bone, muscle, and fat. They will have a 3D body scan. They will wear tight clothes and a shower cap. They will stand on a platform while sensors take pictures of their body.

Key Dates

Start date

Apr 21, 2025

Status verified

Dec 2025

Primary completion

May 1, 2027

Completion

May 1, 2027

Study Design

Enrollment

80 participants (estimated)

Arms

• Arm: Healthy Volunteers
  Male and female ages 9-14

Primary Outcome Measure

The primary endpoint is to obtain high-quality BMC-mcDESPOT and C-NODDI MRI data from up to 30 female and up to 30 male participants between 9 and 14 years old. [ Time Frame: 1 year of recruitment ]

Central Contacts

• Tina Gupta, M.D.
  (301) 451-0481
  [email protected]

Locations (1)

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