Cannabis and Processing Emotions Study

Part of paid clinical trials in Auburn, Alabama.

Sponsor
Auburn University
Study ID
NCT06907979
Status
Recruiting
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Conditions

  • Cannabis Use Disorder, Severe

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • TMS - Sham — DEVICE
    For sham TMS, participants will receive a placebo version of either cTBS or iTBS (in a counterbalanced order). To do this, we will use the "placebo" side of the TMS coil, which produces the same sound volume and sequence as active TMS but does not induce neuromodulatory effects due to using the opposite side of the TMS coil as the "active" side TMS coil. To simulate somatosensory effects of active TMS, sham TMS also use superficial stimulation with the same pulse sequence via a small electrode placed on the target region underneath the coil.
  • TMS - Active iTBS — DEVICE
    Trains consisting of bursts of three stimuli at 50 Hz repeated at 5 Hz frequency delivered at 110% of measured individual motor threshold in 20 x 2-second trains with 8-second intertrain intervals (192 seconds total)
  • TMS - Active cTBS — DEVICE
    Trains consisting of bursts of three stimuli at 50 Hz repeated at 5 Hz frequency delivered at 110% of measured individual motor threshold in 1 x 40-second train (40 seconds total)

Study Details

The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using a non-invasive form of neuromodulation called transcranial magnetic stimulation (TMS). The main question it aims to answer is: -Does manipulating neural activity in the medial orbitofrontal cortex of the brain affect cannabis use-related problem recognition? Researchers will compare three forms of theta burst stimulation (TBS; sham, intermittent, and continuous) in each participant to see if manipulations in neural activity lead to changes in cannabis use-related problem recognition. Participants will complete a screening interview about their mental health and substance use history and complete four in-person laboratory sessions, which involve questionnaires, four brief magnetic resonance imaging (MRI) scans, three TBS sessions, and three electroencephalogram (EEG) sessions. Participants will also be asked to provide urine samples and take saliva and/or breathalyzer tests at some of the lab visits.

Key Dates

Start date
Jan 22, 2026
Status verified
May 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
24 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Sham Comparator: Sham Theta Burst Stimulation (TBS)
  • Experimental: Intermittent Theta Burst Stimulation (iTBS)
  • Experimental: Continuous Theta Burst Stimulation (cTBS)

Primary Outcome Measure

Cerebral blood flow (CBF) in the medial orbitofrontal cortex [ Time Frame: Lab Visits 2 (day 8), 3 (day 15), and 4 (day 22) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Auburn University Neuroimaging CenterAuburnAlabama36849
Brandon Schermitzler, M.S.
[email protected]
334-844-6642

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By research site
Auburn University Neuroimaging Center· Auburn, AL

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