The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Boston Children's Hospital
Study ID
NCT06899971
Status
Not Yet Recruiting

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Conditions

  • Brain Injury
  • Cardiac Surgery Requiring Cardiopulmonary Bypass
  • Congenital Heart Defect

Eligibility Criteria

Sex
ALL
Age
N/A - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • Collecting discarded blood samples — OTHER
    Discarded blood samples will be collected from routine clinical labs collected before and after surgery.

Study Details

Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid much attention. This study is to determine the relationship between specific proteins in the blood and brain injury in patients less than 18-year-old undergoing heart surgery.

Key Dates

Start date
May 1, 2026
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Cardiac Surgery Patients
    Patients less than 18 years old who undergo cardiac surgical procedures on cardiopulmonary bypass.

Primary Outcome Measure

Characterization of postoperative neurological impairment [ Time Frame: 24 hours following surgery ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Boston Children's HospitalBostonMassachusetts02115
Koichi Yuki, MD
[email protected]
617-355-6115

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By research site
Boston Children's Hospital· Boston, MA

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