ALS Research Collaborative

Part of paid clinical trials in Watertown, Massachusetts.

Sponsor
ALS Therapy Development Institute
Study ID
NCT06885918
Status
Recruiting
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Conditions

  • ALS (Amyotrophic Lateral Sclerosis)
  • ALS With Frontotemporal Dementia (ALS/FTD)
  • Amyotrophic Lateral Sclerosis
  • Motor Neuron Disease
  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

The goal of this natural history study is to learn more about the biological and clinical aspects of amyotrophic lateral sclerosis (ALS). This study's findings will help with drug discovery, biomarker discovery, and outcome measure validation. Adults living with ALS, other motor neuron diseases (MND), a known mutation related to ALS and healthy volunteers contribute prospective and retrospective data to this study remotely. The study is sponsored and conducted by the ALS Therapy Development Institute.

Key Dates

Start date
Sep 12, 2014
Status verified
Mar 2025
Primary completion
Jan 31, 2035
Completion
Jan 31, 2035

Study Design

Enrollment
2,000 participants (estimated)

Arms

  • Arm: Person living with ALS/MND
    An adult over the age of 18, that has received a diagnosis of ALS or other Motor Neuron Disease from a practicing physician.
  • Arm: Asymptomatic gene carrier
    An adult over the age of 18 who does not have symptoms of ALS and carries a mutation known to be associated with ALS
  • Arm: Healthy Volunteer
    An adult over the age of 18 who does not have any biological connection to ALS or other Motor Neuron Disease, and no significant health problems.

Primary Outcome Measure

ALS Functional Rating Scale - Revised (ALSFRS-R) [ Time Frame: Monthly, through study completion, an average of 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
ALS Therapy Development InstituteWatertownMassachusetts02472
Alan S Premasiri, M.S.
[email protected]
6174417200
Fernando G Vieira, M.D. (PRINCIPAL_INVESTIGATOR)

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