A Study to Evaluate INCB177054 in Participants With Select Advanced or Metastatic Solid Tumors

Part of paid clinical trials in Los Angeles, California.

Sponsor
Incyte Corporation
Study ID
NCT06873789
Phase
PHASE1/PHASE2
Status
Active Not Recruiting

Conditions

  • Advanced Solid Tumors
  • Metastatic Solid Tumors
  • Solid Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • INCB177054 — DRUG
    INCB177054 will be administered at protocol defined dose.
  • Retifanlimab — DRUG
    Retifanlimab will be administered at protocol defined dose.

Study Details

This study will be conducted to evaluate INCB177054 given as monotherapy or in combination with retifanlimab in participants with select advanced or metastatic solid Tumors.

Key Dates

Start date
Jun 30, 2025
Status verified
Mar 2026
Primary completion
May 8, 2026
Completion
May 8, 2026

Study Design

Enrollment
9 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Part 1a: Dose Escalation monotherapy
    INCB177054 at the protocol-defined dose strength based on cohort assignment.
  • Experimental: Part 1b: Pharmacodynamic cohort
    INCB177054 at the protocol-defined dose strength based on cohort assignment.
  • Experimental: Part 1c: Dose Expansion monotherapy
    INCB177054 at the protocol-defined dose strength based on cohort assignment.
  • Experimental: Part 2a: Dose Escalation combination
    INCB177054 in combination with retifanlimab at the protocol-defined dose strength based on cohort assignment.
  • Experimental: Part 2b: Dose Expansion combination
    INCB177054 in combination with retifanlimab at the protocol-defined dose strength based on cohort assignment.

Primary Outcome Measure

Number of participants with Dose Limiting Toxicities (DLTs) [ Time Frame: Up to 28 days ]

Locations (9)

FacilityCityStateZIPSite coordinators
The Angeles Clinic and Research InstituteLos AngelesCalifornia90025-
Valkyrie Clinical TrialsPanorama CityCalifornia91402-
University of Florida Health Shands HospitalGainesvilleFlorida32610-
Cancer and Hematology Centers of Western Michigan-Start MidwestGrand RapidsMichigan49546-
Hackensack University Medical CenterHackensackNew Jersey07601-
Carolina Bio OncologyHuntersvilleNorth Carolina28078-
Providence Cancer Institute Franz ClinicPortlandOregon97213-
Upmc CancercenterPittsburghPennsylvania15232-
South Texas Accelerated Research TherapeuticsSan AntonioTexas78229-

Find similar trials in Los Angeles, CA

By research site
The Angeles Clinic and Research Institute· Los Angeles, CAValkyrie Clinical Trials· Panorama City, CAUniversity of Florida Health Shands Hospital· Gainesville, FLCancer and Hematology Centers of Western Michigan-Start Midwest· Grand Rapids, MIHackensack University Medical Center· Hackensack, NJCarolina Bio Oncology· Huntersville, NC

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