Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults

Part of paid clinical trials in West Lafayette, Indiana.

Sponsor
Purdue University
Study ID
NCT06873204
Status
Not Yet Recruiting

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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Soluble Arabinoxylan — DIETARY_SUPPLEMENT
    10 grams of soluble arabinoxylan diluted in 200 mL of water, twice daily for 3 consecutive weeks.
  • Rice Bran — DIETARY_SUPPLEMENT
    10 grams of rice bran fiber diluted in 200 mL of water, twice daily for 3 consecutive weeks.
  • Maltodextrin (Placebo) — DIETARY_SUPPLEMENT
    10 grams of maltodextrin diluted in 200 mL of water, twice daily for 3 consecutive weeks.

Study Details

The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota. The soluble fiber in cereal by-products, arabinoxylan (AX), is known to be beneficial for generally promoting gut health. However, it is unclear whether consuming rice bran (RB), the source of AX, is equally helpful or better than consuming the extracted form of AX. This study aims to reveal the potential benefit of insoluble cereal bran fiber ingredients by comparing the effect of soluble arabinoxylan fiber alone and the mostly insoluble rice bran fiber, containing arabinoxylan, on intestinal health and gut microbiota. A placebo (maltodextrin) will be used as a control, with no significant changes expected in this group for the evaluated outcomes. Participants will: * Consume two different fiber supplements (soluble arabinoxylan or stabilized rice bran) as well as a placebo (maltodextrin) for 3 weeks each, separated by a 2-week washout period. * Provide blood and stool samples at six different time points. * Complete a food and gastrointestinal symptom diary during the intervention periods.

Key Dates

Start date
Jul 31, 2025
Status verified
Jun 2025
Primary completion
Oct 31, 2025
Completion
Oct 31, 2025

Study Design

Enrollment
25 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Soluble Arabinoxylan
    Participants in this arm will receive soluble arabinoxylan for 3 consecutive weeks.
  • Experimental: Rice Bran
    Participants in this arm will consume rice bran fiber for 3 consecutive weeks.
  • Placebo Comparator: Maltodextrin
    Participants in this arm will consume maltodextrin for 3 consecutive weeks.

Primary Outcome Measure

Comparison of two test fibers (insoluble cereal bran and soluble arabinoxylan) and a control (maltodextrin) on gut beneficial bacteria [ Time Frame: From enrollment to the end of treatment at 13 weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Clinical Research Center at Purdue UniversityWest LafayetteIndiana47907
Robin L Rhine
[email protected]
765-494-6275

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By research site
Clinical Research Center at Purdue University· West Lafayette, IN

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