External Nitric Oxide Measurement Through SNO Degradation

Part of paid clinical trials in Indianapolis, Indiana.

Sponsor
Indiana University
Study ID
NCT04903535
Status
Enrolling By Invitation

Conditions

  • Healthy
  • Unconscious

Eligibility Criteria

Sex
ALL
Age
1 Day - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Alonefire SV003 10W 365nm UV Flashlight — DEVICE
    Investigator will use a Nitric Oxide Analyzer while attached to a small suction port on the subject's ear lobe to be tested for Nitric Oxide. After getting the baseline assay, the investigator will shine a low-intensity UV Flashlight (Alonefire SV003 10W 365nm UV Flashlight) at the ear lobe for 10 seconds, repeated three times at 20 second intervals, to determine if there is photobleaching. Then the assay will then be performed on the opposite ear lobe. Fifteen minutes after the third UV flashlight exposure, the investigator will collect air from the subject's ear during photolysis into a 20mL glass syringe (once from each ear). Fifteen minutes after the third UV flashlight exposure, the investigator will collect air from the subject's ear during photolysis into a 20mL glass syringe (once from each ear). The subject and the investigator will wear UV goggles during the experiment.

Study Details

In this study, we aim to explore the feasibility of a novel, noninvasive SNO assay to acquire physiological SNO quantification from various parts of the human body and test this new method of analysis. This study aims to help with the currently cumbersome and invasive procedures used to measure SNOs in the body. The proposed activities do not unnecessarily duplicate previous experiments.

Key Dates

Start date
May 10, 2021
Status verified
Dec 2025
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
150 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Healthy Volunteers
    Study will enroll to test the assay

Primary Outcome Measure

Change in Nitric Oxide during UV light exposure [ Time Frame: 30 minutes ]

Locations (2)

FacilityCityStateZIPSite coordinators
Riley Hospital for ChildrenIndianapolisIndiana46202-
Wells Center for Pediatric ResearchIndianapolisIndiana46202-

Find similar trials in Indianapolis, IN

By research site
Riley Hospital for Children· Indianapolis, INWells Center for Pediatric Research· Indianapolis, IN

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