Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT06865222
Status
Recruiting
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Conditions

  • Post COVID-19 Condition

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) - 2 weeks — PROCEDURE
    The Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) will be administered through an FDA-approved Transcranial Magnetic Stimulation (TMS) medical device. Results of the baseline EEG will be uploaded to NoetherTech's EMBP software on the Mayo Clinic campus, and transferred to Noethertech servers for TMS parameter determination TMS treatment will be one 30 min session per day, 5 days per week (Monday-Friday), for 2 weeks.
  • Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) - 4 weeks — PROCEDURE
    The Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) will be administered through an FDA-approved Transcranial Magnetic Stimulation (TMS) medical device. Results of the baseline EEG will be uploaded to NoetherTech's EMBP software on the Mayo Clinic campus, and transferred to Noethertech servers for TMS parameter determination TMS treatment will be one 30 min session per day, 5 days per week (Monday-Friday), for 4 weeks.

Study Details

The purpose of this study is to test if Variable Pulse TMS (Transcranial Magnetic Stimulation) can result in objective improvements in patients with Post COVID Syndrome (PCS).

Key Dates

Start date
Jul 22, 2025
Status verified
Aug 2025
Primary completion
Jan 31, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Anosmia
    Subjects Olfactory Threshold Test scores correspond to Anosmia or Hyposmia
  • Experimental: Tinnitus
    Subjects have \>0 score on Tinnitus Handicap Inventory (not present prior to COVID infection)
  • Experimental: Fatigue
    Subjects have Total Modified Fatigue Impact Scale (MFIS) Score of 40 or above

Primary Outcome Measure

Change in University of Pennsylvania Smell Identification Test (UPSIT) Olfactory Threshold Test score [ Time Frame: Baseline, 2 weeks, 10 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in RochesterRochesterMinnesota55905
Ryan T. Hurt (PRINCIPAL_INVESTIGATOR)

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