Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Tufts Medical Center
Study ID
NCT05866952
Status
Recruiting
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Conditions

  • Dyspnea
  • Post COVID-19 Condition
  • Post Viral Fatigue
  • Post-Acute COVID-19

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Accepted

Interventions

  • Computed Tomography of the Chest — DIAGNOSTIC_TEST
    Quantitative Computed Tomography of the chest in the inspiratory and expiratory phases will be performed to assess regional lung ventilation as well as pulmonary vascular volume and distribution

Study Details

Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations

Key Dates

Start date
Jun 5, 2023
Status verified
Jul 2025
Primary completion
May 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: Post-Acute Sequelae of SARS-CoV-2 (PASC) Group
    Subjects with PASC with a documented history of COVID-19 and persistent symptoms of fatigue, dyspnea, and/or exercise intolerance
  • Arm: Control: Fully recovered COVID-19
    Subjects with a history of COVID-19 who have fully recovered from COVID-19 with no post-acute sequelae of SARS-Cov-2
  • Arm: Control: No history of COVID-19
    Healthy subjects without a documented history of COVID-19, no current symptoms, and a normal baseline High resolution CT of the chest

Primary Outcome Measure

Measures of regional lung ventilation [ Time Frame: 1 day ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Tufts Medical CenterBostonMassachusetts02111
Bipin Malla
Maher Ghamloush, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Tufts Medical Center· Boston, MA

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