Brain and Behavior Influences on Obesity Development From Infancy Through Childhood

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT06861868
Status
Recruiting
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Conditions

  • Obesity and Overweight

Eligibility Criteria

Sex
ALL
Age
7 Years - 12 Years
Healthy Volunteers
Accepted

Interventions

  • fMRI cue reactivity task — OTHER
    Measures effect of food and non-food cues on brain activation
  • fMRI go no go task — OTHER
    Measures effect of food and non-food cues on inhibitory responses and brain activation
  • Ad libitum meal test — OTHER
    Measures effect of exposure to multi-item buffet meal on food intake
  • Eating in the absence of hunger test — OTHER
    Measures effect of exposure to palatable snacks on food intake

Study Details

The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.

Key Dates

Start date
Dec 2, 2024
Status verified
May 2026
Primary completion
Mar 31, 2029
Completion
Mar 31, 2029

Study Design

Enrollment
210 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Single arm
    Single arm

Primary Outcome Measure

Meal test intake as assessed by total kilocalories consumed [ Time Frame: Day 1 ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.BaltimoreMaryland21205-
Johns Hopkins University School of MedicineBaltimoreMaryland21287-
Rhode Island HospitalProvidenceRhode Island02903
Viren D'Sa, MD
[email protected]
312-371-4178
Daphne Koinis-Mitchell, PhD
[email protected]
401-793-8632
Viren D'Sa, MD (PRINCIPAL_INVESTIGATOR)
Daphne Koinis-Mitchell, PhD (SUB_INVESTIGATOR)
University of WashingtonSeattleWashington98109-

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Hugo W. Moser Research Institute at Kennedy Krieger, Inc.· Baltimore, MDJohns Hopkins University School of Medicine· Baltimore, MDRhode Island Hospital· Providence, RIUniversity of Washington· Seattle, WA

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