Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults

Part of paid clinical trials in Newark, Delaware.

Sponsor
University of Delaware
Study ID
NCT06860724
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • NG-nitro-L-arginine methyl ester (L-NAME) — OTHER
    Acute local perfusion of L-NAME (15 mM) directly to the microvasculature will be used to inhibit NO synthase.

Study Details

The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age adults and the extent to which this association is impacted by major depressive disorder (MDD).

Key Dates

Start date
Jan 6, 2025
Status verified
Feb 2025
Primary completion
Dec 30, 2030
Completion
Dec 1, 2031

Study Design

Enrollment
18 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: healthy adults
    non-depressed healthy adults
  • Experimental: adults with major depressive disorder
    adults with major depressive disorder (unmedicated)

Primary Outcome Measure

Nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) [ Time Frame: immediately before and after the 14-day testing cycle ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of DelawareNewarkDelaware19713
Jody Greaney, PhD
[email protected]
302-831-2193

Find similar trials in Newark, DE

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
University of Delaware· Newark, DE

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