THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT06859710
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Abuse, Drug
  • Pain

Eligibility Criteria

Sex
ALL
Age
21 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Placebo — DRUG
    Vaporized Placebo
  • THC — DRUG
    Vaporized THC (20 mg)
  • CBD 20 mg — DRUG
    Vaporized CBD (20 mg)
  • CBD 40 mg — DRUG
    Vaporized CBD (40 mg)
  • CBD 80 mg — DRUG
    Vaporized CBD (80 mg)

Study Details

The purpose of this research is to assess the impact of CBD on the effects of THC.

Key Dates

Start date
Nov 5, 2025
Status verified
Sep 2025
Primary completion
Sep 1, 2027
Completion
Sep 1, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Placebo
    0 mg THC, 0 mg CBD
  • Active Comparator: THC
    20 mg THC, 0 mg CBD
  • Active Comparator: CBD 20
    0 mg THC, 20 mg CBD
  • Active Comparator: CBD 40
    0 mg THC, 40 mg CBD
  • Active Comparator: CBD 80
    0 mg THC, 80 mg CBD
  • Active Comparator: THC with CBD 20
    20 mg THC, 20 mg CBD
  • Active Comparator: THC with CBD 40
    20 mg THC, 40 mg CBD
  • Active Comparator: THC with CBD 80
    20 mg THC, 80 mg CBD

Primary Outcome Measure

Subject-rated drug effects of abuse liability [ Time Frame: 3 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCLA Center for Cannabis and CannabinoidsLos AngelesCalifornia90095
Ziva D Cooper, PhD
[email protected]
(310) 794 -1497
Vince Acebo
[email protected]

Find similar trials in Los Angeles, CA

By research site
UCLA Center for Cannabis and Cannabinoids· Los Angeles, CA

Related Studies