A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity

Part of paid clinical trials in Santa Ana, California.

Sponsor
Eli Lilly and Company
Study ID
NCT06859268
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Retatrutide — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss. The study will have two treatment phases: an 80 week lead-in phase in which all participants will take retatrutide dose 1 and a 36 week randomized, double-blinded phase in which participants will either take retatrutide dose 1, retatrutide dose 2, or switch to placebo. Participation in the study will last around 125 weeks.

Key Dates

Start date
Mar 5, 2025
Status verified
Feb 2026
Primary completion
Apr 30, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
643 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide Dose 1
    Participants will receive retatrutide dose 1 administered subcutaneously (SC) for 116 weeks
  • Experimental: Retatrutide Dose 1 to Retatrutide Dose 2
    Participants will receive retatrutide dose 1 administered SC for 80 weeks, then retatrutide dose 2 administered SC for an additional 36 weeks
  • Placebo Comparator: Retatrutide Dose 1 to Placebo
    Participants will receive retatrutide dose 1 administered SC for 80 weeks, then placebo administered SC for an additional 36 weeks

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Week 0, Week 116 ]

Locations (33)

FacilityCityStateZIPSite coordinators
Southern California Clinical ResearchSanta AnaCalifornia92701-
University of Colorado Anschutz Medical CampusAuroraColorado80045-
CMR of Greater New Haven, LLCHamdenConnecticut06517-
ALL Medical Research, LLCCooper CityFlorida33024-
Florida International Medical ResearchCoral GablesFlorida33134-
Renstar Medical ResearchOcalaFlorida34470-
Charter Research - Winter ParkOrlandoFlorida32803-
Metabolic Research Institute, Inc.West Palm BeachFlorida33401-
Kubost Clinical Research - MariettaMariettaGeorgia30062-
North Georgia Clinical ResearchWoodstockGeorgia30189-
Pacific Diabetes & Endocrine CenterHonoluluHawaii96817-
Alliance for Multispecialty Research, LLCOak BrookIllinois60523-
Springfield Clinic Main CampusSpringfieldIllinois62703-
Alliance for Multispecialty Research, LLCLexingtonKentucky40509-
L-MARC Research CenterLouisvilleKentucky40213-
Pennington Biomedical Research CenterBaton RougeLouisiana70808-
Care Access - Lake Charles (Bayou Pines)Lake CharlesLouisiana70601-
Massachusetts General HospitalBostonMassachusetts02114-
Alliance for Multispecialty Research, LLCKansas CityMissouri64114-
Vector Clinical TrialsLas VegasNevada89128-
Dent Neurosciences Research Center, IncAmherstNew York14226-
Carteret Medical GroupMorehead CityNorth Carolina28557-
Care Access - RaleighRaleighNorth Carolina27607-
Tekton Research, LLC.MooreOklahoma73160-
Altoona Center For Clinical ResearchDuncansvillePennsylvania16635-
Care Access - Rapid CityRapid CitySouth Dakota57701-
Alliance for Multispecialty Research, LLCKnoxvilleTennessee37909-
Care Access - HoustonHoustonTexas77054-
Southern Endocrinology AssociatesMesquiteTexas75149-
Sleep Therapy Research CenterSan AntonioTexas78229-
National Clinical Research, IncRichmondVirginia23294-
Northwest Clinical Research CenterBellevueWashington98007-
Central Washington Health Services Association d/b/a Confluence HealthWenatcheeWashington98801-

Find similar trials in Santa Ana, CA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Southern California Clinical Research· Santa Ana, CAUniversity of Colorado Anschutz Medical Campus· Aurora, COCMR of Greater New Haven, LLC· Hamden, CTALL Medical Research, LLC· Cooper City, FLFlorida International Medical Research· Coral Gables, FLRenstar Medical Research· Ocala, FL

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