A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive Patients

Part of paid clinical trials in Andalusia, Alabama.

Sponsor
Novartis Pharmaceuticals
Study ID
NCT06857955
Phase
PHASE2
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Saline — OTHER
    0.9% sodium chloride saline solution
  • QCZ484 — DRUG
    Solution of Injection

Study Details

The purpose of this study is to evaluate the efficacy, safety and tolerability of QCZ484 or placebo, given subcutaneously, every 6 months, at different dose levels in patients with mild to moderate hypertension

Key Dates

Start date
Mar 26, 2025
Status verified
May 2026
Primary completion
Jan 29, 2027
Completion
Apr 5, 2028

Study Design

Enrollment
385 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Placebo Comparator: Placebo Control
    Placebo
  • Experimental: QCZ484 Dose 1
    QCZ484 Dose 1 solution for injection
  • Experimental: QCZ484 Dose 2
    QCZ484 Dose 2 solution for injection
  • Experimental: QCZ484 Dose 3
    QCZ484 Dose 3 solution for injection
  • Experimental: QCZ484 Dose 4
    QCZ484 Dose 4 solution for injection
  • Experimental: QCZ484 Dose 5
    QCZ484 Dose 5 solution for injection

Primary Outcome Measure

Change in Mean 24hr SBP by ABPM [ Time Frame: Baseline, Month 3 ]

Locations (72)

FacilityCityStateZIPSite coordinators
SEC Clinical Research LLCAndalusiaAlabama36420-
UAB St VincentsBirminghamAlabama35211-
Longwood ResearchHuntsvilleAlabama35801-
The Center for Clinical TrialsSaralandAlabama36571-
Elite Clinical StudiesPhoenixArizona85018-
Synexus Clinical Research US IncTucsonArizona85741-
NICRs Research CenterGarden GroveCalifornia92844-
Valiance Clinical ResearchHuntington ParkCalifornia90255-
Downtown L A Research Center IncLos AngelesCalifornia90017-
Clinical Trials Research SacramentoSacramentoCalifornia95821-2134-
Encompass Clinical ResearchSpring ValleyCalifornia91978-1522-
Clinical Research of Brandon LLCBrandonFlorida33511-
ALL Medical Research LLCCooper CityFlorida33024-
National Research InstituteHialeahFlorida33013-
Cen Exel RCAHollywoodFlorida33024-
East Coast Institute for ResearchJacksonvilleFlorida32216-
Entrust Clinical ResearchMiamiFlorida33176-
Inpatient Research Clinical LLCMiami LakesFlorida33014-
Suncoast Clinical ResearchNew Port RicheyFlorida34452-
Renstar Medical ResearchOcalaFlorida34471-
American Research Centers of FLPembroke PinesFlorida33027-
Cen Exel FCRTampaFlorida33613-
Cardiology Partners Clinical Research InstituteWellingtonFlorida33449-
Centricity ResearchColumbusGeorgia31904-
Javara ResearchFayettevilleGeorgia30214-
Velocity Clinical ResearchSavannahGeorgia31406-
Solaris Clinical ResearchMeridianIdaho83646-
Cedar Crosse Research CtChicagoIllinois60607-
Eagle Clinical ResearchChicagoIllinois60621-
Synexus Clinical Research USEvansvilleIndiana47714-
Velocity Clin Research Sioux CitySioux CityIowa51106-
Alliance for Multispecialty ResearchWichitaKansas67207-
Velocity Clinical Res Baton RougeBaton RougeLouisiana70809-
Southern Clin Research ClinicZacharyLouisiana70791-
Ascension Saint Agnes Heart CareBaltimoreMaryland21229-
Anderson Medical ResearchFt. WashingtonMaryland20744-
Capitol Cardiology AssociatesLanhamMaryland20706-
AA Medical Research CenterFlintMichigan48504-
Oakland Medical Research CenterTroyMichigan48085-
Trinity Health Michigan HeartYpsilantiMichigan48197-
Synexus Clinical Research US IncRichfieldMinnesota55432-
Healthcare Research Network II LLCHazelwoodMissouri63042-
Jefferson City Medical GroupJefferson CityMissouri65109-
Clin Rsrch Consult a JCCT CompanyKansas CityMissouri64111-
Velocity Clin at Pioneer Heart InstLincolnNebraska68506-
AMR Las VegasLas VegasNevada89119-
CenExel HRIBerlinNew Jersey08009-
Velocity Clinical ResearchBinghamtonNew York13905-
Novant Health Heart Vas InstCharlotteNorth Carolina28204-
Monroe Biomedical ResearchMonroeNorth Carolina28112-
Burke Primary CareMorgantonNorth Carolina28655-
Accellacare of Rocky MountRocky MountNorth Carolina27804-
Accellacare of SalisburySalisburyNorth Carolina28144-
CR Services Acquisition USColumbusOhio43213-
Conrad Clinical ResearchEdmondOklahoma73013-
Velocity Clinical Research MedfordMedfordOregon97504-
TCV Clinical StudiesLinwoodPennsylvania19061-
Velocity Clinical ResearchUnionSouth Carolina29379-
Clinical Neuroscience Solutions IncMemphisTennessee38119-
Velocity Clinical Research AustinAustinTexas78759-
North Hills Medical Research IncBedfordTexas76021-
Synergy Group Medical LLCHoustonTexas77061-
Biopharma InformaticKatyTexas77479-
Synergy Groups Medical LLCMissouri CityTexas77459-
Clinical Trials of TexasSan AntonioTexas78229-
Sun Research InstituteSan AntonioTexas78205-
AMR LaytonLaytonUtah84041-
Manassas Clinical Research CenterManassasVirginia20110-
Dominion Medical AssociatesRichmondVirginia23219-
Centricity Research Suffolk Fam MedSuffolkVirginia23435-
MultiCare Ins Research InnovationPuyallupWashington98372-
Velocity Clinical Research SpokaneSpokaneWashington99218-

Find similar trials in Andalusia, AL

By condition
Hypertension (high blood pressure)
By specialty
CardiologyHeart disease
By research site
SEC Clinical Research LLC· Andalusia, ALUAB St Vincents· Birmingham, ALLongwood Research· Huntsville, ALThe Center for Clinical Trials· Saraland, ALElite Clinical Studies· Phoenix, AZSynexus Clinical Research US Inc· Tucson, AZ

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