Impacts of Opioids on Respiratory Drive During Sleep

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Brigham and Women's Hospital
Study ID
NCT06854211
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Obstructive Sleep Apnea (OSA)
  • Opioids

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Morphine p.o. — DRUG
    Morphine 50mg PO will be given on sleep study night.
  • Placebo — DRUG
    Placebo will be given on the sleep study night.

Study Details

The investigators are studying the impact that opioids have on breathing during sleep in healthy participants and those diagnosed with obstructive sleep apnea.

Key Dates

Start date
Jul 1, 2026
Status verified
Jan 2026
Primary completion
Jan 1, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
26 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Morphine
  • Placebo Comparator: Placebo

Primary Outcome Measure

The change in ventilation (L) per minute during stable sleep with morphine versus placebo. [ Time Frame: From enrollment to the end of treatment at 6 weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Brigham and Women's HospitalBostonMassachusetts02115
Nicole Calianese
[email protected]
617-732-8977
Danny J Eckert, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Brigham and Women's Hospital· Boston, MA

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