Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT06842784
Status
Recruiting
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Conditions

  • Aging
  • Heat Strain
  • Heat Stress
  • Hyperthermia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Ambient heat stress — OTHER
    3-hour ambient heating in 44°C and 20% relative humidity

Study Details

Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuated skin blood flow and sweating responses when exposed to heat, resulting greater increase in core body temperature. Despite these observations, relatively little is known about the risk for myocardial ischemia potentially contributing to the aforementioned higher morbidity and mortality in older adults during heat waves. The broad objective of this work is to determine the impact of ambient heat exposure on myocardial blood flow and flow reserve in young and older adults. Aim 1 will test the hypothesis that older adults exhibit attenuated myocardial flow reserve compared to young adults during heat stress. Aim 2 will determine if the percent of maximal myocardial flow reserve (assess via vasodilator stress) during heat exposure is higher in older adults compared to young adults. The expected outcome from this body of work will improve our understanding of the consequences of aging on cardiovascular responses to ambient heat stress.

Key Dates

Start date
Feb 3, 2025
Status verified
Feb 2025
Primary completion
Feb 1, 2026
Completion
Feb 1, 2027

Study Design

Enrollment
24 participants (estimated)

Arms

  • Arm: Young participants
    Individuals aged 18-39 years
  • Arm: Older participants
    Individuals aged 65 years or older

Primary Outcome Measure

Myocardial flow reserve [ Time Frame: The difference in the change from baseline to a vasodilator stress test and the change from baseline to after 3-hours of heat stress. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Texas Health Presbyterian Hospital DallasDallasTexas75231-

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By research site
Texas Health Presbyterian Hospital Dallas· Dallas, TX

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