Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
Gopalkumar Rakesh
Study ID
NCT06830980
Status
Recruiting
Apply to this trial

Conditions

  • HIV
  • Methamphetamine Use Disorders

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • intermittent theta burst stimulation (iTBS) — DEVICE
    iTBS is an excitatory TMS paradigm that delivers 1800 pulses to the left dlPFC. Participants will receive 2 iTBS sessions separated by 50 minutes.
  • continuous theta burst stimulation (cTBS) — DEVICE
    cTBS is an inhibitory TMS paradigm that delivers 1800 pulses to the frontal pole. Participants will receive 2 iTBS sessions separated by 50 minutes.
  • Sham TMS — DEVICE
    Sham TMS delivered with the MagVenture B65 A/P coil

Study Details

The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.

Key Dates

Start date
Mar 11, 2025
Status verified
Oct 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Other: Group 1
    Group 1 will receive actual TMS (iTBS and cTBS) on days 2 and 3 and sham TMS on day 4.
  • Other: Group 2
    Group 2 will receive actual TMS (iTBS and cTBS) on days 2 and 4 and sham TMS on day 3.
  • Other: Group 3
    Group 3 will receive sham TMS on day 2 and actual TMS (iTBS and cTBS) on days 3 and 4.

Primary Outcome Measure

Cue-induced methamphetamine craving [ Time Frame: Baseline and before and after each TMS session up to 4 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UK Department of PsychiatryLexingtonKentucky40509
Annette Garth, CRC
[email protected]
859-382-7611
Gopalkumar Rakesh, MD
[email protected]

Find similar trials in Lexington, KY

By condition
HIV
By specialty
Infectious disease
By research site
UK Department of Psychiatry· Lexington, KY

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