Olfactory Training in Mild Cognitive Impairment

Part of paid clinical trials in New York, New York.

Sponsor
Jeffrey Motter
Study ID
NCT06825403
Status
Recruiting
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Conditions

  • Mild Cognitive Impairment

Eligibility Criteria

Sex
ALL
Age
55 Years - 89 Years
Healthy Volunteers
Not accepted

Interventions

  • Olfactory Memory Training — BEHAVIORAL
    Participants will complete 48 OMT sessions at home lasting approximately 10 minutes each over 3 months.
  • Visual Memory Training — BEHAVIORAL
    Participants will complete 48 VMT sessions at home lasting approximately 10 minutes each over 3 months.

Study Details

Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline. Memory for new odors is particularly diminished in these individuals. Existing treatments for AD do not improve these symptoms. A targeted treatment for improving sense of smell, called 'Olfactory Training', has been used to improve sense of smell in people with various forms of smell loss, though it is not known whether it can improve smell abilities and thinking abilities in patients who are at high risk of developing Alzheimer's disease. The investigators will conduct a randomized clinical trial with patients who have mild cognitive impairment (MCI). This is an early phase of memory loss that is worse than normal aging and may precede Alzheimer's disease. Patients will be randomized to either olfactory memory training or visual memory training for 3 months, with a final follow-up visit at 6 months. This study will attempt to determine if olfactory training is a useful for improving smell abilities, thinking abilities, and everyday functioning by examining change in these outcomes over time.

Key Dates

Start date
Aug 7, 2025
Status verified
Jul 2025
Primary completion
Mar 31, 2028
Completion
Mar 31, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Olfactory Memory Training
  • Active Comparator: Visual Memory Training

Primary Outcome Measure

Change in Preclinical Alzheimer's Cognitive Composite 5 (PACC5) [ Time Frame: Baseline, 3 Months, 6 Months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
New York State Psychiatric InstituteNew YorkNew York10032
Jeffrey Motter, PhD
[email protected]
6467748654

Find similar trials in New York, NY

By research site
New York State Psychiatric Institute· New York, NY

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