Effect of the Stellate Ganglion Block on the Retinal Microcirculation

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT06797752
Status
Recruiting
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Conditions

  • Intracerebral Hemorrhage
  • OCTA
  • Severe Brain Injury
  • Subarachnoid Hemorrhage

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • OCTA Scan — DEVICE
    Optical Coherence Tomography Angiography before and after receiving the stellate ganglion nerve block.

Study Details

Surges in the sympathetic nervous system occur at the ictus of a variety of neurological critical illnesses including intracranial hemorrhage and ischemic stroke. It is hypothesized that these exaggerated increases in sympathetic nervous activity produce maladaptations that promote secondary brain injury. One of these possible mechanisms include diffuse vasospasm that cause cerebral ischemia. Hence, methods to abrogate the sympathetic nervous system in this context are under active investigation. One possible method is the regional anesthesia technique of the stellate ganglion nerve block, which is ordinarily used for complex regional pain syndrome, but has been shown to reduce cerebral sympathetic activity and reduces vasospasm in patients with subarachnoid hemorrhage. However, its effect on the microcirculation is not clear. Hence, we propose to study patients receiving the stellate ganglion nerve block as part of their standard medical care and to image their retinal microcirculation before and after the procedure using Optical Coherence Tomography Angiography (OCTA).

Key Dates

Start date
Oct 7, 2024
Status verified
Nov 2025
Primary completion
Oct 7, 2026
Completion
Oct 7, 2026

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Intervention Group
    Patients receiving the stellate ganglion block

Primary Outcome Measure

Vascular and Perfusion Density [ Time Frame: One day ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UT Southwestern Medical CenterDallasTexas75235
Noah Jouett, DO, PhD
[email protected]
214-645-7011
Noah Jouett, DO, PhD (PRINCIPAL_INVESTIGATOR)

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UT Southwestern Medical Center· Dallas, TX

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