Brain Blood Flow and Lactate in Non-obese and Obese Subjects

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT06791837
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • EXERCISE — BEHAVIORAL
    each group will undergo a max test and a submaximal exercise test

Study Details

Cerebral blood flow (CBF) is essential for maintaining brain health and function, as it ensures delivery oxygen and nutrients necessary to support neuronal activity. Reduced CBF can impair the brain's ability to meet its metabolic demands, leading to deficits in cognitive ability. Impairments in CBF are associated with cognitive decline and neurodegenerative disease such as Alzheimer's and dementia. Many factors influence CBF, but recently lactate has emerged as a key player. Blood glucose has long been considered the primary fuel for the brain, but emerging evidence indicates that lactate may be the preferred fuel for neurons, and lactate may become even more important under stressful conditions. Individuals with obesity often have impaired lactate metabolism resulting in higher resting blood lactate concentrations and reduced ability to clear lactate after a physiological stress. At the same time, it is known that exercise is a powerful intervention for improving lactate metabolism. Thus, this project seeks to investigate the role of lactate in brain blood flow in individuals with and without obesity as well as establish if short term exercise training (individuals with obesity only) will alter circulating lactate concentrations at rest and in response to exercise.

Key Dates

Start date
May 1, 2025
Status verified
Nov 2025
Primary completion
Mar 1, 2027
Completion
Mar 1, 2027

Study Design

Enrollment
24 participants (estimated)

Arms

  • Arm: non-obese
    individuals with a BMI\<25 kg/m2
  • Arm: obese
    individuals with a BMI 30-40 kg/m2

Primary Outcome Measure

brain blood flow [ Time Frame: over the 30 minutes of testing ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MissouriColumbiaMissouri65211
Matt McDonald, MS
[email protected]
618-581-5501
Jill Kanaley, PhD
[email protected]
5738822519
Jill Kanaley, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Columbia, MO

By condition
Obesity / overweight
By specialty
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By research site
University of Missouri· Columbia, MO

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