Genetic and Clinical Characterization of Type 1 and 2 Narcolepsy in Adult and Pediatric Black and North African Populations

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT06786377
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
6 Years - 21 Years
Healthy Volunteers
Accepted

Interventions

  • saliva sampling — GENETIC
    saliva sampling

Study Details

Narcolepsy type 1 (NT1) is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, and hallucinations while awake. It results from the loss of orexin-producing neurons in the hypothalamus, leading to a deficiency of the neuropeptide orexin/hypocretin. Studies show differences in the clinical presentation of NT1 between Caucasian and African American populations, highlighting the importance of research into genetic and clinical characteristics specific to Black and North African populations. A genetic study in these populations could identify novel genes associated with NT1 and NT2, providing crucial information for personalized diagnosis and treatment. This would fill a knowledge gap and promote more effective interventions for individuals of African descent, contributing to a better understanding of narcolepsy globally.

Key Dates

Start date
Jan 30, 2025
Status verified
Jan 2025
Primary completion
Jan 30, 2026
Completion
Jan 30, 2026

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: narcolepsy patients
    50 narcolepsy patients will be included in the study at Robert Debré Hospital
  • Arm: control patients
    150 control patients will be included in the study at Robert Debré Hospital

Primary Outcome Measure

Describe the genetic and clinical features of type 1 and 2 narcolepsy in Black and North African populations [ Time Frame: 12 months ]

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