A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Part of paid clinical trials in Birmingham, Alabama.
- Sponsor
- Celgene
- Study ID
- NCT06782490
- Phase
- PHASE2
- Status
- Recruiting
Conditions
- Multiple Sclerosis Spasticity
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 70 Years
- Healthy Volunteers
- Not accepted
Interventions
- BMS-986368 — DRUGSpecified dose on specified days
- Placebo — DRUGSpecified dose on specified days
Study Details
The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986368 in participants with Multiple Sclerosis Spasticity
Key Dates
- Start date
- Jun 5, 2025
- Status verified
- Jun 2026
- Primary completion
- May 26, 2027
- Completion
- Jun 9, 2027
Study Design
- Enrollment
- 200 participants (estimated)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: Administration of BMS-986368 Dose A
- Experimental: Administration of BMS-986368 Dose B
- Experimental: Administration of BMS-986368 Dose C
- Placebo Comparator: Placebo
Primary Outcome Measure
Change from baseline in Total Numeric-transformed Modified Ashworth Scale-Most Affected Lower Limb (TNmAS-MALL) score [ Time Frame: At week 6 ]
Central Contacts
- BMS Clinical Trials Contact Center www.BMSClinicalTrials.com855-907-3286
- First line of the email MUST contain NCT # and Site #.
Locations (15)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Alabama Neurology Associates | Birmingham | Alabama | 35209 | Emily Riser, Site 0033 205-803-2210 |
| Perseverance Research Center,LLC | Scottsdale | Arizona | 85253 | Barry Hendin, Site 0050 602-258-3368 |
| Local Institution - 0017 | Aurora | Colorado | 80045 | - |
| Aqualane Clinical Research | Naples | Florida | 34105 | Matthew Baker, Site 0068 239-529-6780 |
| USF Health | Tampa | Florida | 33612 | Derrick Robertson, Site 0015 813-974-6378 |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | Sharon Lynch, Site 0016 913-588-6980 |
| Neurology Center of New England | Foxborough | Massachusetts | 02035 | Andrew Taylor, Site 0049 781-551-5812 |
| Local Institution - 0071 | Southfield | Michigan | 48034 | Site 0071 |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Robert Naismith, Site 0018 314-362-3293 |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | Shahla Hosseini, Site 0002 412-427-7087 |
| Local Institution - 0069 | Columbus | Ohio | 43235 | - |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | Jacqueline Nicholas, Site 0039 614-566-1255 |
| Local Institution - 0067 | Philadelphia | Pennsylvania | 19107 | Site 0067 |
| Hope Neurology | Knoxville | Tennessee | 37922 | Sibyl Wray, Site 0003 865-218-6222 |
| EvergreenHealth Medical Center | Kirkland | Washington | 98034 | Theodore Brown, Site 0001 425-899-5385 |