Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balance Problems

Part of paid clinical trials in Houston, Texas.

Sponsor
Weinberg Medical Physics LLC
Study ID
NCT06779188
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Aging
  • Balance Deficits

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Magnetic Stimulation — DEVICE
    TMS (in the form of theta burst stimulations) will be delivered over Supplementary Motor Area while the subject is seated in the Treatment group. TMS is capable to induce neuroplastic facilitatory changes in the brain that last beyond the duration of stimulation. TMS will be delivered once daily, 5 days per week, for 4 weeks.
  • Transcranial Magnetic Stimulation Sham — DEVICE
    Sham TMS will be delivered in the sham group using a sham coil once daily, 5 days per week, for 4 weeks.

Study Details

The goal of this study is to learn if manipulating the brain using magnets works to treat balance impairment, a major cause of falls, in older adults with balance problems. The technique to manipulate the brain using magnets is known as transcranial magnetic stimulation or TMS. The main questions this study aims to answer are: * How does TMS change communication between brain areas? * Does TMS improve balance ability in older adults with balance problems? Researchers will compare the TMS group to a placebo group to see if manipulating the brain using magnets works to treat balance impairment. Participants will: * Receive TMS or placebo stimulation for 4 weeks. * Visit the laboratory for checkups and tests 3 times.

Key Dates

Start date
May 6, 2025
Status verified
May 2025
Primary completion
May 1, 2026
Completion
May 31, 2026

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment group
    Participants in this group will receive transcranial magnetic stimulation (TMS) once daily, 5 days a week. TMS will be in the form of accelerated repetitive TMS. TMS is a safe technique when handled by experts.
  • Sham Comparator: Sham group
    Participants in this group will receive sham (placebo) TMS once daily, 5 days a week.

Primary Outcome Measure

Electroencephalography functional connectivity [ Time Frame: Before and immediately-after the intervention and at 3- month follow-up ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Center for Neuromotor and Biomechanics Research at the University of HoustonHoustonTexas77204
Pranav J Parikh, MBBS, PhD
[email protected]
713-743-0503
Pranav J Parikh, MBBS, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Houston, TX

By research site
The Center for Neuromotor and Biomechanics Research at the University of Houston· Houston, TX

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