Endodontic Microsurgery

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
Mark Schachman
Study ID
NCT06776289
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Apical Periodontitis

Eligibility Criteria

Sex
ALL
Age
18 Years - 90 Years
Healthy Volunteers
Not accepted

Interventions

  • Platelet rich fibrin — BIOLOGICAL
    Platelet rich fibrin will be used to fill an osteotomy after endodontic microsurgery is completed.

Study Details

Current literature on platelet rich fibrin (PRF) use in apicoectomies, also known as endodontic microsurgery, is sparse. PRF use in oral surgery or periodontal surgery has been more thoroughly researched. Whether it is able to reduce post-op pain or if it improves success rate in endodontic microsurgery is not well known. It is also not well known if it will be able to increase the rate of healing. This study will evaluate the success of endodontic microsurgery with and without PRF.

Key Dates

Start date
Mar 31, 2026
Status verified
Jan 2026
Primary completion
Jul 28, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Microsurgery with Platelet Rich Fibrin
    Patents will have a blood draw completed so that PRF can be made. Endodontic microsurgery will then be completed. Prior to closing the flap, PRF will be placed in the osteotomy.
  • No Intervention: Microsurgery Alone
    Endodontic microsurgery will be completed without PRF. The osteotomy will remain empty as per standard procedure.

Primary Outcome Measure

Change in bone deposition using voxel-based imposition [ Time Frame: 6 months, 12 months, and 18 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Kentucky College of Dentistry Endodontics DivisionLexingtonKentucky40508
Mark Schachman, DMD
[email protected]
8593238575
Dawn Dawson, RDH, CCRC
[email protected]
8593235409

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By research site
University of Kentucky College of Dentistry Endodontics Division· Lexington, KY

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