New Mechanisms of Obesity

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT06768827
Status
Recruiting
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Conditions

  • Insulin Resistance
  • Obesity and Obesity-related Medical Conditions
  • Obesity and Overweight

Eligibility Criteria

Sex
ALL
Age
15 Years - 22 Years
Healthy Volunteers
Not accepted

Interventions

  • Lactulose Oral Product — OTHER
    Each arm will undergo a study to induce colonic fermentation through lactulose at the beginning and at the end of the 12 weeks.

Study Details

Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.

Key Dates

Start date
Nov 13, 2025
Status verified
Jan 2026
Primary completion
Mar 31, 2030
Completion
Mar 31, 2030

Study Design

Enrollment
55 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Remote physical exercise
  • Active Comparator: Control physical exercise

Primary Outcome Measure

CHANGES IN ADIPOSE TISSUE LIPOLYSIS (ATL) [ Time Frame: 6 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale UniversityNew HavenConnecticut06520-

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By research site
Yale University· New Haven, CT

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