The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT06765642
Status
Recruiting
Apply to this trial

Conditions

  • Arm Weakness as a Consequence of Stroke
  • Brain Stimulation
  • Chronic Stroke Patients
  • Chronic Stroke Survivors
  • Motor Learning
  • Stroke
  • Stroke Patients
  • Transcranial Magnetic Stimulation
  • Transcranial Magnetic Stimulation Repetitive

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Magnetic Stimulation — DIAGNOSTIC_TEST
    The use of this approach aims to potentially maximize motor recovery in chronic stroke by harnessing corticospinal plasticity and modulating motor learning behavior.

Study Details

The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.

Key Dates

Start date
Jun 9, 2025
Status verified
May 2026
Primary completion
Apr 13, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
26 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Non-invasive Brain Stimulation Modalities
    All participants will undergo three non-invasive brain stimulation modalities: 1. Focal conventional iTBS over the ipsilesional motor cortex (i.e., a single bout of 600 pulses over a single spot; FiTBS600). 2. Focal high dose iTBS over the ipsilesional motor cortex (i.e. 4 bouts of 600 pulses over a single spot = 2400 pulses; FiTBS2400). 3. Diffuse high dose iTBS over the ipsilesional motor cortex (i.e. 4 bouts of 600 pulses over 4 spots: 600 pulses/spot × 4 spots = 2400 pulses; DiTBS2400)

Primary Outcome Measure

To determine whether there is overall stimulation effect among three stimulation paradigms (FiTBS600; FiTBS2400; DiTBS2400) on the ipsilesional corticospinal excitability of a hand muscle. [ Time Frame: Baseline, prior to and after intervention (Pre0 and Pre1; 45 minutes apart) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke University Medical CenterDurhamNorth Carolina27710
Wayne Feng, MD
[email protected]
919 681 1700

Find similar trials in Durham, NC

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Duke University Medical Center· Durham, NC

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