fMRI Neurofeedback With Matter Neuroscience App

Conditions

• Depression
• Depression Mild
• Depression Moderate

Eligibility Criteria

Sex

ALL

Age

18 Years - 80 Years

Healthy Volunteers

Not accepted

Interventions

• Matter Neuroscience App — DEVICE
  An iPhone smartphone application
• Stock Photos — OTHER
  Stock Photos
• No Home Training — OTHER
  No Home Training
• Personal Photos — DEVICE
  Personal Photos
• Home Training — OTHER
  Home Training

Study Details

Study will utilize an app, Matter Neuroscience, designed to help users with depression understand positive emotions and the neurotransmitters that create them. We hope to learn the safety and efficacy of neurofeedback for treating depression and lay the groundwork for a pivotal clinical trial.

Key Dates

Start date

Aug 12, 2025

Status verified

May 2026

Primary completion

Jun 15, 2027

Completion

Jun 15, 2028

Study Design

Enrollment

240 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Arms

• No Intervention: Arm 1A. No home training, no neurofeedback, no photos, no repeated scans
  No home training, no neurofeedback, no photos, no repeated scans
• Experimental: Arm 1B. No home training no neurofeedback, repeated scans, personal photos
  No home training no neurofeedback, repeated scans, personal photos
• Experimental: Arm 2. No home training, neurofeedback, stock photos, repeated scans
  No home training, neurofeedback, stock photos, repeated scans
• Experimental: Arm 3. No home training, neurofeedback, personal photos, repeated scans
  No home training, neurofeedback, personal photos, repeated scans
• Experimental: Arm 4. Home training, no neurofeedback, stock photos, repeated scans
  Home training, no neurofeedback, stock photos, repeated scans
• Experimental: Arm 5. Home training, neurofeedback, stock photos, repeated scans
  Home training, neurofeedback, stock photos, repeated scans
• Experimental: Arm 6. Home training, no neurofeedback, personal photos, repeated scans
  Home training, no neurofeedback, personal photos, repeated scans
• Experimental: Arm 7. Home training, neurofeedback, personal photos, repeated scans
  Home training, neurofeedback, personal photos, repeated scans

Primary Outcome Measure

Determine the safety and efficacy of neurofeedback for treating depression through MADRS scale changes [ Time Frame: Screening, Baseline, Immediate Post, One Month Post, Three Month and Optional Six Month ]

Central Contacts

• Stephanie Wan
  650 491 6339
  [email protected]
• Nick Bassano
  650-800-6920
  [email protected]

Locations (1)

Find similar trials in Stanford, CA

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